New Publication on Deep Learning to identify metabolic pathways of cells from label-free imaging

Congratulations to Walsh Lab members Linghao Hu and Daniela de Hoyos, as well as our collaborators Yuanjiu Lei and A. Phillip West (Jackson Laboratory) on our publication in APL Bioengineering, “3D convolutional neural networks predict cellular metabolic pathway use from fluorescence lifetime decay data“. In this paper, we show how label-free autofluroescence lifetime imaging of …

Congratulations Nianchao!

Congratulations to Nianchao Wang, on the successful defense of his Master’s Thesis. His project was to develop a method to compare instance segmentation results, so that different image segmentation algorithms can be quantitatively compared. If you’re interested in learning more about his work, it is published in PlosOne:

SPIE Photonics West 2024

The Walsh Lab was busy at SPIE Photonics West this January. Four members of the lab attended, Oscar Benavides, Alex Walsh, Elizabeth Bullard, and Blanche ter Hofstede. Keep an eye out for the online publication of our presentations and proceedings papers! Paper 12827-30PLμTO: a polarized light-sheet microscopy and tomography system for versatile multi-scale and high-throughput …

Publication: “Label-free spatially maintained measurements of metabolic phenotypes in cells”

We have a new publication (https://doi.org/10.3389/fbioe.2023.1293268) on our work related to autofluorescence lifetime microscopy for imaging cellular metabolism. In this paper, we define NAD(P)H and FAD fluorescence lifetime changes with perturbations to inhibit or enhance the metabolic pathways of glycolysis, oxidative phosphorylation, and glutaminolysis. Additionally, we develop and test conventional feature-based machine learning models to …

Melody Yeh – Freshman Gathright Scholar

Congratulations to undergraduate researcher Melody Yeh, who was awarded the Freshman Gathright Scholar award for the College of Engineering. https://tamupkp.wordpress.com/2023/10/02/2023-gathright-deans-excellence-award-winners/ This highly competitive award is sponsored by Chapter 053 of The Honor Society of Phi Kappa Phi and TAMU’s LAUNCH: Academic Excellence. The awards recognize and celebrate outstanding first- and second- year students with exceptional …

Graduate Research Symposium 2023

We had fun at the Biomedical Engineering Department’s Graduate Research Symposium. 100% of the QOIL graduate students and post-doc trainees participated as attendees, presenters, and poster judges! Presentations:(Poster) Fast Fluorescence Imaging of Metabolic Coenzymes, Anna Theodossiou, Jocelyn Martinez, and Alex J. Walsh(Poster) Unveiling the Metabolic Diversity in Cancer: Quantifying Cancer Stem Cells and Bulk Cancer …

Carley Conover REU Presentation

REU student, Carley Conover, gave an exciting poster presentation on her summer research at the Engineering REU Poster Session!

Paper published on FLIM analysis methods for machine learning

Congratulations to Blanche ter Hofstede and Linghao Hu on the publication of their paper, “Comparison of phasor analysis and biexponential decay curve fitting of autofluorescence lifetime imaging data for machine learning prediction of cellular phenotypes” in Frontiers in Bioinformatics! In this paper, we compared two different fluorescence lifetime imaging analysis techniques, phasor analysis and exponential …

Congratulations Linghao!

Congratulations to Linghao Hu on the successful defense of his dissertation, “Development of Fluorescence Lifetime Imaging for Identifying and Predicting Cellular Metabolic Perturbations!